Sell Phenacetin Cas:62-44-2
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Buy wholesale Phenacetin Crystal and Powder CAS 62-44-2
Phenacetin powder for sale. Buy wholesale Phenacetin Crystal and Powder CAS 62-44-2. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. Sell Phenacetin Cas:62-44-2
Phenacetin (acetophenetidin, N-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. Sell Phenacetin Cas:62-44-2 It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, and by the U.S. Food and Drug Administration in 1983). Phenacetin powder for sale
History Phenacetin powder
Phenacetin was introduced in 1887 in Elberfeld, Germany by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties. Phenacetin powder for sale
Prior to World War One, Britain imported phenacetin from Germany. During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain. Phenacetin powder for sale
Known mechanism of action Sell Phenacetin Cas:62-44-2
Phenacetin’s analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia. Phenacetin powder for sale
In vivo, one of two reactions occur. Usually phenacetin’s ether is cleaved to leave paracetamol (acetaminophen), which is the clinically relevant analgesic. A minority of the time the acetyl group is removed from the amine, producing carcinogenic p-phenetidine. This reaction is quite rare, however, as evidenced by the fact that the drug was on the market for almost 100 years before a statistical link was established, when Canada, followed by the United States, withdrew it from the market. Phenacetin powder for sale
Preparation Phenacetin powder
The first synthesis was reported in 1878 by Harmon Northrop Morse.
Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallized from water. Phenacetin powder for sale
Uses of Phenacetin powder
Vicks cold tablets, containing: salicylamide, phenacetin 2½ grs., pyrilamine maleate, caffeine, ephedrine sulphate, magnesium hydroxide, aluminum hydroxide complex (U.S. Pat. 2,446,981). That patent number is from 1948; these tablets would have been made shortly thereafter. Sell Phenacetin Cas:62-44-2
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an A.P.C., or “aspirin-phenacetin-caffeine” compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia. Phenacetin powder for sale
In the United States, the Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, due to its carcinogenic and kidney-damaging properties. It was also banned in India. As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity. Phenacetin powder for sale
Phenacetin has been used as a cutting agent to adulterate cocaine in the UK and Canada, due to the similar physical properties. There, it has been given the nickname “magic”.
Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research. Phenacetin powder for sale
In Canada phenacetin is used as a laboratory reagent, and in a few hair dye preparations (as a stabilizer for hydrogen peroxide). While it is considered a prescription drug, no marketed drugs contain phenacetin. Phenacetin powder for sale
Safety Phenacetin powder
Phenacetin, and products containing phenacetin, have been shown in an animal model to have the side effect and after-effect of carcinogenesis. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially urothelial carcinoma of the renal pelvis. Phenacetin is classified by the International Agency for Research on Cancer (IARC) as carcinogenic to humans. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases. In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis, or dissolution of blood cells, while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement system. Phenacetin powder for sale
Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. This is a condition which results in destruction of some or all of the renal papillae in the kidneys. It is believed that the metabolite p-phenetidine is at least partly responsible for these effects. Phenacetin powder for sale
One notable death that can possibly be attributed to the use of this drug was that of the aviation pioneer Howard Hughes. He had been using phenacetin extensively for the treatment of chronic pain; it was stated during his autopsy that phenacetin use may have been the cause of his kidney failure. Phenacetin powder for sale
| Description | ||
|---|---|---|
| IC50 & Target |
|
In Vitro
Phenacetin shows inhibitory activity for COX-3 with an IC50 value of 102 μM in insect cells .
Phenacetin is a substrate widely used as an in vitro and in vivo probe to measure the activity of CYP1A2, because the metabolism of phenacetin to acetaminophen is thought to be a selective CYP1A2-mediated reaction Phenacetin powder for sale
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo Sell Phenacetin Cas:62-44-2
Phenacetin exhibits elimination half-life (rat 2.06 h) and Cmax (6,728.3 μg/L) following oral administration (rat 20 mg/kg)
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats (180-200 g) |
| Dosage: | 20 mg/kg |
| Administration: | Oral administration (Pharmacokinetic Analysis) |
| Result: | T1/2 (2.06 hours), Cmax (6,728.3 μg/L). |
Molecular Weight
179.22
Formula
C10H13NO2
CAS No.
SMILES
CC(NC1=CC=C(OCC)C=C1)=O
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| Sell Phenacetin Cas:62-44-2 | -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL (557.97 mM)
H2O : 0.67 mg/mL (3.74 mM; Need ultrasonic)
*“≥” means soluble, but saturation unknown.
Stock Solutions
| ConcentrationSolventMass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.5797 mL | 27.8987 mL | 55.7973 mL |
| 5 mM | 1.1159 mL | 5.5797 mL | 11.1595 mL |
| 10 mM | 0.5580 mL | 2.7899 mL | 5.5797 mL |
Quick Details
- Pro Name: US warehouse Phenacetin shipping Shiny…
- CasNo:62-44-2
- Molecular Formula:C8H9NO2
- Appearance: white powder
- Application:Use for parmaceutical intermediates or…
- Delivery Time:7dasy
- PackAge: as you requiry
- Port: Shanghai
- ProductionCapacity:90000 Metric Ton/Day
- Purity:99.9%
- Storage: room temperature
- Transportation: shipping by air, by sea, and other way
- LimitNum:1 Kilogram
- Moisture Content:0.03
- Impurity:0.001
- Phenacetin MF:C9H11NO2
- Phenacetin MW:165.19
- Phenacetin name: Phenacetin
- Phenacetin standard: USP/BP
- Phenacetin Packing:25KG/BAG
- Phenacetin Storage: Dry and cool place and keep away from …
- Phenacetin Sample: Available
- Phenacetin Shelf life:2YEARS
| CBNumber: | CB44796969 |
| Chemical Name: | Phenacetin CAS 62-44-2 |
| Molecular Formula: | C10H13NO2 |
| Formula Weight: | 179.21572 |
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Phenacetin | ≥99%(HPLC)
| Cas No. | 62-44-2 | SDF | Download SDF |
| PubChem ID | 4754 | Appearance | Powder |
| Formula | C10H13NO2 | M.Wt | 179.22 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Acetophenetidin | ||
| Solubility | DMSO : ≥ 100 mg/mL (557.97 mM) H2O : 0.67 mg/mL (3.74 mM; Need ultrasonic) *”≥” means soluble, but saturation unknown. |
||
| Chemical Name | N-(4-ethoxyphenyl)acetamide | ||
| SMILES | CCOC1=CC=C(C=C1)NC(=O)C | ||
| Standard InChIKey | CPJSUEIXXCENMM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. Sell Phenacetin Cas:62-44-2 |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Target: COX Phenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with phenacetin nephritis as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].
References: |
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| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.5797 mL | 27.8987 mL | 55.7973 mL | 111.5947 mL | 139.4934 mL |
| 5 mM | 1.1159 mL | 5.5797 mL | 11.1595 mL | 22.3189 mL | 27.8987 mL |
| 10 mM | 0.558 mL | 2.7899 mL | 5.5797 mL | 11.1595 mL | 13.9493 mL |
| 50 mM | 0.1116 mL | 0.558 mL | 1.1159 mL | 2.2319 mL | 2.7899 mL |
| 100 mM | 0.0558 mL | 0.279 mL | 0.558 mL | 1.1159 mL | 1.3949 mL |
| * Note: If you are in the process of experiment, it’s necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it’s can get a better solubility within lower of Concentrations. Sell Phenacetin Cas:62-44-2 | |||||
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Phenacetin
Usually In Stock- CAS RN:
- 40674-52-0
- Formula:
- C10H13NO2
- InChIKey:
- CPJSUEIXXCENMM-UHFFFAOYSA-N
Other Compounds (11)
-
Phenacetin
In Stock- CAS RN:
- 69323-74-6
- Formula:
- C₁₀H₈D₅NO₂
-
What exactly is Phenacetin?
Phenacetin is a pain-killing and fever-reducing medication. It is a COX-3 inhibitor that is specific. Sell Phenacetin Cas:62-44-2
The History of Phenacetin
Phenacetin was developed in 1887 in Elberfeld, Germany, by the German company Bayer and was utilized predominantly as an analgesic. It was among the very first synthetic remedies for reducing fever that came into the market. It’s also believed as one of the very first non-opioid analgesics with no anti-inflammatory properties. Sell Phenacetin Cas:62-44-2
Before World War One, Britain brought Phenacetin into the country from Germany. During the war, a group comprising Jocelyn Field Thorpe and Martha Annie Whiteley created the synthesizer in Britain. Sell Phenacetin Cas:62-44-2
Mechanism of action for Phenacetin
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N-Nitrosophenacetin
Usually In Stock- CAS RN:
- 15862-11-0
- Formula:
- C10H12N2O3
- InChIKey:
- ANFMPQMRMNEDCD-UHFFFAOYSA-N
-
-
-
Phenacetin-ethoxy-1-13C
In Stock- CAS RN:
- 72156-72-0
- Formula:
- C10H13NO2
- InChIKey:
- CPJSUEIXXCENMM-LBPDFUHNSA-N
-
N-(Pivaloyloxy)phenacetin
- CAS RN:
- 102725-57-5
- Formula:
- C15H21NO4
- InChIKey:
- MPNGGGGXPLRSTK-UHFFFAOYSA-N
-
3-Hydroxyphenacetin phosphate
- CAS RN:
- 72755-24-9
- Formula:
- C10H14NO6P
- InChIKey:
- PPVYXKJZXVUWHJ-UHFFFAOYSA-N
-
N-Hydroxyphenacetin glucuronide
- CAS RN:
- 69783-19-3
- Formula:
- C16H21NO9
- InChIKey:
- CGQCCRQISHOSGC-HAFSJTIUSA-N
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Aminopyrine mixture with caffeine and phenacetin
- CAS RN:
- 8075-94-3
- Formula:
- C31H40N8O5
- InChIKey:
- CSYGDFOVWMCVDH-UHFFFAOYSA-N
-
Aspirin mixture with caffeine, cinnamedrine and phenacetin
- CAS RN:
- 83514-22-1
- Formula:
- C46H55ClN6O9
- InChIKey:
- GXVYKGFDXIZMAF-CAKSNXNRSA-N
Phenacetin is a non-opioid analgesic without anti-inflammatory properties.Phenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and labora Sell Phenacetin Cas:62-44-2
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IRMS to study a common cocaine cutting agent: phenacetin.[Pubmed:27860349]
Drug Test Anal. 2017 Mar;9(3):479-484.
Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It frequently appears in cocaine seizures as a cutting agent. Following both sanitary and intelligence motivations, this molecule was chosen for this study, and stable isotopes seemed to be the most appropriate tool. A total of 228 seized samples were collected over a 6-year period, and 8 standards of known origin were purchased. They were submitted to gas chromatography (GC) or elemental analysis – isotope ratio mass spectrometry (EA-IRMS) measurements, depending on their complexity. Stable isotope ratios of carbon, hydrogen, and nitrogen for a part of the sample set, were acquired. The isotopic values of Phenacetin standards acquired from various providers located worldwide are quite spread, which indicates that stable isotopes could be used to discriminate manufacturers. However, the measured values of most of the seized samples are concentrated in a narrow range, tending to demonstrate that Phenacetin is smuggled from a single source or similar ones. Consequently, stable isotopes could only be used to exclude that several samples come from a common source. Copyright (c) 2016 John Wiley & Sons, Ltd.
Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.[Pubmed:26955604]
J Adv Pharm Technol Res. 2016 Jan-Mar;7(1):6-12.
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, Phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-Phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: Phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of Phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers. Sell Phenacetin Cas:62-44-2
Electro-catalytic oxidation of phenacetin with a three-dimensional reactor: Degradation pathway and removal mechanism.[Pubmed:26950512]
Chemosphere. 2016 Jun;152:17-22.
Phenacetin is a common analgesic, anti-arthritic and anti-rheumatic drug. This study dealt with the degradation of Phenacetin in alkaline media using a three-dimensional reactor with particle electrodes. Particular attention was paid to the degradation pathway and the reaction mechanism in the system. Liquid chromatography coupled with time-of-flight mass spectrometry was used to identify the intermediates. The Phenacetin was observed to be firstly cut off the branch chains main by direct oxidation, and then the intermediates further degraded to ring opening products by hydroxyl radical resulting from indirect oxidation and finally mineralized to CO2, H2O. A possible removal mechanism was proposed that direct and indirect oxidation together did effect on the pollutants with oxygen. Sell Phenacetin Cas:62-44-2
A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy.[Pubmed:28217547]
J Adv Pharm Technol Res. 2017 Jan-Mar;8(1):2-7.
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and Phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters.
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