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4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP) 1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanylfuranylfentanylbenzylfentanyl and homofentanyl, among others. It is an N-protected derivative of 4-anilinopiperidine which can be readily converted to fentanyl or related analogues in several straightforward synthetic steps. It was classified as a DEA List 1 Chemical in 2022 and is also controlled in various other jurisdictions. Its possession, sale and importation are consequently heavily regulated throughout much of the world.[1] 1-Boc-4-AP has also been identified as an impurity in other designer drug products, though it is unclear if it has any pharmacological activity in its own right.

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

4-Anilino-1-Boc-piperidine (1-Boc-4-AP)

1-Boc-4-piperidone is used as a precursor in the synthesis of synthetic drugs and as a building block for the preparation of selective ligands.

Application

1-Boc-4-piperidone, a pharma building block,may be used in the synthesis of (3E,5E)-3,5-bis(2,5-dimethoxybenzylidene)-1-t-butoxycarbonylpiperidin-4-one (RL197). It may also be used in the synthesis of spirorifamycins containing a piperidine ring structure
Synonyms
Synonyms
  • 4-ANBocP
  • N-Boc-4-AP
  • 1-Boc-4-(Phenylamino)piperidine
  • tert-Butyl 4-(phenylamino)piperidine-1-carboxylate
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
  • 4-Anilino-1-Boc-piperidine (1-Boc-4-AP)
Technical Information
Formal Name
4-(phenylamino)-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester
CAS Number
125541-22-2
Molecular Formula
C16H24N2O2
Formula Weight
276.4
Purity
≥98%
A crystalline solid
  • DMF: 15 mg/ml
  • DMSO: 25 mg/ml
  • Ethanol: 25 mg/ml
  • Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
249 nm
SMILES
O=C(OC(C)(C)C)N(CC1)CCC1NC2=CC=CC=C2
InChi Code
InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-11-9-14(10-12-18)17-13-7-5-4-6-8-13/h4-8,14,17H,9-12H2,1-3H3
InChi Key
HTIWISWAPVQGMI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 5 years
Certificates of Analysis & Batch Specific Data

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